KMID : 0988920040020010026
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Intestinal Research 2004 Volume.2 No. 1 p.26 ~ p.30
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The Influence of Inflammatory Bowel Disease and Its Treatment with 5-Aminosalicylic Acid on Pregnancy and Fetal Outcome
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Choi Ji-Hoon
Yang Suk-Kyun Myung Seung-Jae Cho Yoon-Kyung Lee Yun-Jung Byeon Jeong-Sik Lee Gin-Hyug Jung Hwoon-Yong Hong Weon-Seon Kim Jin-Ho Min Young-Il
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Abstract
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Background/Aims: 5-Aminosalicylic acid (5-ASA) preparations are the first-line drugs in the treatment of inflammatory bowel disease (IBD). The aim of this study was to examine the influence of IBD and its treatment with 5-ASA on pregnancy and fetal outcome.
Methods: A total of 56 patients (ulcerative colitis 41, Crohn¡¯s disease 15) experienced 84 pregnancies among 634 female patients with IBD between June 1989 and August 2003. The outcomes of 42 pregnancies exposed to 5-ASA during pregnancy were compared with those of 42 non-exposed pregnancies.
Results: Pregnancy outcomes were not different between the exposed and non-exposed pregnancies in terms of live birth (85.7% vs 80.9%), abortion (11.9% vs 19.0%), stillbirth (2.4% vs 0%), preterm delivery (11.1% vs 5.9%), low birth weight (11.1% vs 8.8%), congenital malformation (2.8% vs 2.9%), and aggravation of disease during pregnancy (21.4% vs 16.7%). These figures appear to be similar to those of general population.
Conclusions: Neither ulcerative colitis nor Crohn¡¯s disease has any significant impact on pregnancy outcome, and 5-ASA does not increase the risk of congenital malformation.
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KEYWORD
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Inflammatory bowel disease, Ulcerative colitis, Crohn¡¯s disease, Pregnancy, 5-Aminosalicylic acid
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